FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term porphobilinogen synthase activity ID (Ontology) GO:0004655 (Gene Ontology)
Definition Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen.[ EC:4 ]
Also Known As"aminolevulinate dehydratase activity" ; "delta-aminolevulinic acid dehydratase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 porphobilinogen synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | porphobilinogen synthase activity
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  carbon-oxygen lyase activity
   |__hydro-lyase activity
       |__porphobilinogen synthase activity  1 rec.
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Is a hydro-lyase activity
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Synonyms
  • "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" RELATED[ EC:4 ]
    "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" RELATED[ EC:4 ]
    "5-levulinic acid dehydratase activity" RELATED[ EC:4 ]
    "aminolevulinate dehydratase activity" EXACT
    "aminolevulinic dehydratase activity" RELATED[ EC:4 ]
    "delta-aminolevulinate dehydratase activity" RELATED[ EC:4 ]
    "delta-aminolevulinic acid dehydrase activity" RELATED[ EC:4 ]
    "delta-aminolevulinic acid dehydratase activity" EXACT
    "delta-aminolevulinic dehydratase activity" RELATED[ EC:4 ]
Secondary IDs
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EC:4.2.1.24
KEGG_REACTION:R00036
MetaCyc:PORPHOBILSYNTH-RXN
Reactome:R-HSA-189439 "ALAD condenses 2 dALAs to form PBG"
RHEA:24064