FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term procollagen-proline 4-dioxygenase activity ID (Ontology) GO:0004656 (Gene Ontology)
Definition Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.[ EC:1 ]
Also Known As"procollagen-proline,2-oxoglutarate-4-dioxygenase activity"
Comment
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 procollagen-proline 4-dioxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | procollagen-proline 4-dioxygenase activity
 NOT | enables | procollagen-proline 4-dioxygenase activity
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peptidyl-proline dioxygenase activity
 |__procollagen-proline dioxygenase activity__
 |__peptidyl-proline 4-dioxygenase activity___|
                                              procollagen-proline 4-dioxygenase activity  25 rec.
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Is a procollagen-proline dioxygenase activity
peptidyl-proline 4-dioxygenase activity
Part of
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Synonyms
  • "collagen proline hydroxylase activity" RELATED[ EC:1 ]
    "hydroxylase, collagen proline activity" RELATED[ EC:1 ]
    "peptidyl proline hydroxylase activity" BROAD[ EC:1 ]
    "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" RELATED[ EC:1 ]
    "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT
    "proline hydroxylase activity" BROAD[ EC:1 ]
    "proline protocollagen hydroxylase activity" RELATED[ EC:1 ]
    "proline, 2-oxoglutarate dioxygenase activity" BROAD[ EC:1 ]
    "proline,2-oxoglutarate 4-dioxygenase activity" BROAD[ EC:1 ]
    "prolyl 4-hydroxylase activity" BROAD[ EC:1 ]
    "prolyl hydroxylase activity" BROAD[ EC:1 ]
    "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" BROAD[ EC:1 ]
    "prolylprotocollagen dioxygenase activity" RELATED[ EC:1 ]
    "prolylprotocollagen hydroxylase activity" RELATED[ EC:1 ]
    "protocollagen hydroxylase activity" BROAD[ EC:1 ]
    "protocollagen proline 4-hydroxylase activity" RELATED[ EC:1 ]
    "protocollagen proline dioxygenase activity" RELATED[ EC:1 ]
    "protocollagen proline hydroxylase activity" RELATED[ EC:1 ]
    "protocollagen prolyl hydroxylase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.14.11.2
KEGG_REACTION:R03219
MetaCyc:1.14.11.2-RXN
Reactome:R-HSA-1650808 "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines"
RHEA:18945