FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

CAAX-protein geranylgeranyltransferase activity

ID (Ontology)

GO:0004662 (Gene Ontology)

Definition

Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.[ EC:2 PubMed:8621375 ]

Also Known As

"geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" ; "geranylgeranyltransferase type I activity" ; "GGTase-I activity" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
CAAX-protein geranylgeranyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
contributes_to \| CAAX-protein geranylgeranyltransferase activity

Spanning Tree (Parents/Children)

  protein prenyltransferase activity
   |__protein geranylgeranyltransferase activity
       |__CAAX-protein geranylgeranyltransferase activity  2 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein geranylgeranyltransferase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT "geranylgeranyltransferase type I activity" EXACT "GGTase-I activity" EXACT "GGTaseI activity" EXACT "protein geranylgeranyltransferase type I" RELATED[ EC:2 ] "type I protein geranyl-geranyltransferase activity" RELATED[ EC:2 ]
Secondary IDs

External Crossreferences & Linkouts
	EC:2.5.1.59 MetaCyc:RXN-3701 Reactome:R-HSA-9947999 "FNTA:PGGT1B geranylgeranylates GBP2" Reactome:R-HSA-9954195 "FNTA:PGGT1B geranylgeranylates GBP5"