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General Information
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| Term |
CAAX-protein geranylgeranyltransferase activity |
ID (Ontology) |
GO:0004662 (Gene Ontology) |
| Definition |
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.[ EC:2 PubMed:8621375 ] |
| Also Known As |
"geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" ; "geranylgeranyltransferase type I activity" ; "GGTase-I activity" (for all, see Synonyms field below) |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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| Data Class | Field | Records |
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| Genes (FBgn) | GO_MOLECULAR_FUNCTION | 2 |
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Genes |
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CAAX-protein geranylgeranyltransferase activity (all annotations which use CV term, excluding "NOT" statements) | 2 | contributes_to | CAAX-protein geranylgeranyltransferase activity | 2 |
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Relationships
