FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity ID (Ontology) GO:0004671 (Gene Ontology)
Definition Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.[ EC:2 ]
Also Known As"protein-S-isoprenylcysteine O-methyltransferase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
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methyltransferase activity
 |__S-adenosylmethionine-dependent methyltransferase activity__
protein carboxyl O-methyltransferase activity                  |
 |__protein C-terminal carboxyl O-methyltransferase activity___|
                                                               protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity  1 rec.
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Is a protein C-terminal carboxyl O-methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
Part of
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Synonyms
  • "farnesyl cysteine C-terminal methyltransferase activity" RELATED[ EC:2 ]
    "farnesyl-protein carboxymethyltransferase activity" RELATED[ EC:2 ]
    "farnesylated protein C-terminal O-methyltransferase activity" RELATED[ EC:2 ]
    "isoprenylated protein methyltransferase activity" RELATED[ EC:2 ]
    "isoprenylcysteine carboxylmethyltransferase activity" RELATED[ EC:2 ]
    "prenylated protein carboxyl methyltransferase activity" RELATED[ EC:2 ]
    "prenylated protein methyltransferase activity" RELATED[ EC:2 ]
    "prenylcysteine carboxyl methyltransferase activity" RELATED[ EC:2 ]
    "prenylcysteine carboxylmethyltransferase activity" RELATED[ EC:2 ]
    "prenylcysteine carboxymethyltransferase activity" RELATED[ EC:2 ]
    "prenylcysteine methyltransferase activity" RELATED[ EC:2 ]
    "protein C-terminal farnesylcysteine O-methyltransferase activity" RELATED[ EC:2 ]
    "protein S-farnesylcysteine C-terminal methyltransferase activity" RELATED[ EC:2 ]
    "protein-S-isoprenylcysteine O-methyltransferase activity" EXACT
    "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" RELATED[ EC:2 ]
    "S-farnesylcysteine methyltransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.1.1.100
KEGG_REACTION:R04496
MetaCyc:2.1.1.100-RXN
Reactome:R-HSA-6788650 "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins"
Reactome:R-HSA-9647977 "ICMT methylates S-Farn RAS proteins"
RHEA:21672