FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term cAMP-dependent protein kinase activity ID (Ontology) GO:0004691 (Gene Ontology)
Definition cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.[ PubMed:32935175 PubMed:35053423 PubMed:35805104 ]
Also Known As"3',5' cAMP-dependent protein kinase activity" ; "3',5'-cAMP-dependent protein kinase activity" ; "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 cAMP-dependent protein kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | cAMP-dependent protein kinase activity       --
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  protein serine/threonine kinase activity
   |__cyclic nucleotide-dependent protein kinase activity
       |__cAMP-dependent protein kinase activity  5 rec.
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Is a cyclic nucleotide-dependent protein kinase activity
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Synonyms
  • "3',5' cAMP-dependent protein kinase activity" EXACT
    "3',5'-cAMP-dependent protein kinase activity" EXACT
    "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT
    "AMPK" RELATED[ EC:2 ]
    "ATP:protein phosphotransferase (cAMP-dependent) activity" RELATED[ EC:2 ]
    "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT
    "cyclic AMP-dependent protein kinase activity" EXACT
    "PKA" RELATED[ EC:2 ]
    "PKA C" RELATED[ EC:2 ]
    "protein kinase A activity" BROAD[ EC:2 ]
    "STK22" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.11.11
Reactome:R-HSA-163672 "Phosphorylation of ChREBP at Thr(653) by PKA"
Reactome:R-HSA-163676 "Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA"
Reactome:R-HSA-163773 "PKA tetramer:cAMP phosphorylates PF2K-Pase"
Reactome:R-HSA-177275 "PKA phosphorylates DARPP-32 on Thr34"
Reactome:R-HSA-177284 "PKA phosphorylates PDE4B"
Reactome:R-HSA-432232 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)"
Reactome:R-HSA-5610717 "PKA phosphorylates GLI2"
Reactome:R-HSA-5610720 "PKA phosphorylates GLI3"
Reactome:R-HSA-5610741 "PKA phosphorylates GLI1"
Reactome:R-HSA-5617179 "PRKACA phosphorylates TNNI3"
Reactome:R-HSA-5617182 "PRKACA phosphorylates PLN"
Reactome:R-HSA-5687088 "PKA phosphorylates MAPKAPK5"
Reactome:R-HSA-913451 "IL3RB is phosphorylated on Ser-585"
Reactome:R-HSA-9838321 "PRKACA phosphorylates TFAM in the mitochondrial matrix"
Reactome:R-HSA-9861318 "PKA phosphorylates NOS3 (eNOS) on serine-633"