FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term cGMP-dependent protein kinase activity ID (Ontology) GO:0004692 (Gene Ontology)
Definition cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 cGMP-dependent protein kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | cGMP-dependent protein kinase activity       --
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  protein serine/threonine kinase activity
   |__cyclic nucleotide-dependent protein kinase activity
       |__cGMP-dependent protein kinase activity  4 rec.
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Is a cyclic nucleotide-dependent protein kinase activity
Part of
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Synonyms
  • "3':5'-cyclic GMP-dependent protein kinase activity" RELATED[ EC:2 ]
    "ATP:protein phosphotransferase (cGMP-dependent) activity" RELATED[ EC:2 ]
    "cGMP-dependent protein kinase ibeta activity" RELATED[ EC:2 ]
    "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" RELATED[ EC:2 ]
    "PKG" RELATED[ EC:2 ]
    "PKG 1alpha" RELATED[ EC:2 ]
    "PKG 1beta" RELATED[ EC:2 ]
    "PKG II" RELATED[ EC:2 ]
    "STK23" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.11.12
Reactome:R-HSA-1475422 "PTPS is phosphorylated by cGMP-dependant protein kinase II"
Reactome:R-HSA-1497853 "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II"
Reactome:R-HSA-418442 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release"
Reactome:R-HSA-418549 "PKG1 phosphorylates BK channels"
Reactome:R-HSA-9920025 "PKG phosphorylates NS5"