FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term calcium,diacylglycerol-dependent serine/threonine kinase activity ID (Ontology) GO:0004698 (Gene Ontology)
Definition Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction is activated in the presence of diacylglycerol and calcium.[ PubMed:34834162 ]
Also Known As"calcium-dependent PKC activity" ; "conventional protein kinase C activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 calcium,diacylglycerol-dependent serine/threonine kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | calcium,diacylglycerol-dependent serine/threonine kinase activity       --
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protein serine/threonine kinase activity
 |__diacylglycerol-dependent serine/threonine kinase activity___
 |__calcium-dependent protein serine/threonine kinase activity__|
                                                                calcium,diacylglycerol-dependent serine/threonine kinase activity  3 rec.
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Is a diacylglycerol-dependent serine/threonine kinase activity
calcium-dependent protein serine/threonine kinase activity
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Synonyms
  • "calcium-dependent PKC activity" EXACT
    "conventional protein kinase C activity" EXACT[ PubMed:9601053 ]
Secondary IDs
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Reactome:R-HSA-114683 "Phosphorylation of Platelet Sec-1"
Reactome:R-HSA-114684 "Phosphorylation of Syntaxin-4"
Reactome:R-HSA-1433508 "PKC alpha interacts with and phosphorylates KIT"
Reactome:R-HSA-2179413 "Activated PKC-alpha activate MMP3"
Reactome:R-HSA-416639 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites"
Reactome:R-HSA-421007 "Endocytosis of Ca impermeable AMPA receptors"
Reactome:R-HSA-450550 "PKCalpha phosphorylates HuR"
Reactome:R-HSA-5138432 "DVL2 is phosphorylated by PKC"
Reactome:R-HSA-5218823 "PKC phosphorylates sphingosine kinase 1"
Reactome:R-HSA-5229194 "Depolymerization of lamin filaments after PKC-mediated phosphorylation"
Reactome:R-HSA-74615 "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP"
Reactome:R-HSA-8934446 "Activated PKC phosphorylates SHC1"
Reactome:R-HSA-8986937 "MECP2 is phosphorylated at T308"
Reactome:R-HSA-9005561 "Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308"
Reactome:R-HSA-9010681 "PKC phosphorylates ROBO3.1"