FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term MAP kinase kinase activity ID (Ontology) GO:0004708 (Gene Ontology)
Definition Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a T-X-Y motif in the activation loop of a MAP kinase (MAPK) substrate.[ PubMed:12623839 PubMed:38270553 ]
Also Known As"ERK activator kinase activity" ; "MAPK activator activity" ; "MAPKK activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 MAP kinase kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | MAP kinase kinase activity       --
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  protein kinase activity
   |__protein serine/threonine/tyrosine kinase activity
       |__MAP kinase kinase activity  5 rec.
           |__JUN kinase kinase activity 1 rec.
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Is a protein serine/threonine/tyrosine kinase activity
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Synonyms
  • "ATP:protein phosphotransferase (MAPKKK-activated) activity" RELATED[ EC:2 ]
    "ERK activator kinase activity" EXACT
    "MAP kinase kinase 4 activity" NARROW[ EC:2 ]
    "MAP kinase kinase 7 activity" NARROW[ EC:2 ]
    "MAP kinase or ERK kinase activity" RELATED[ EC:2 ]
    "MAP2K" RELATED[ EC:2 ]
    "MAPK activator activity" EXACT
    "MAPKK" RELATED[ EC:2 PubMed:20811974 ]
    "MAPKK activity" EXACT
    "MAPKK1" RELATED[ EC:2 ]
    "MEK activity" BROAD
    "MEK1" RELATED[ EC:2 ]
    "MEK2" RELATED[ EC:2 ]
    "mitogen-activated protein kinase kinase activity" RELATED[ EC:2 ]
    "MKK" RELATED[ EC:2 ]
    "MKK2" RELATED[ EC:2 ]
    "MKK4" RELATED[ EC:2 ]
    "MKK6" RELATED[ EC:2 ]
    "MKK7" RELATED[ EC:2 ]
    "STK27" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.12.2
MetaCyc:2.7.12.2-RXN
Reactome:R-HSA-1247960 "Activation of p38 MAPK"
Reactome:R-HSA-3238999 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5"
Reactome:R-HSA-448951 "Activation of p38 alpha/beta MAPK"
Reactome:R-HSA-450333 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3"
Reactome:R-HSA-5218804 "p38 MAPK activation by VEGFR"