FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term purine-nucleoside phosphorylase activity ID (Ontology) GO:0004731 (Gene Ontology)
Definition Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.[ EC:2 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 purine-nucleoside phosphorylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | purine-nucleoside phosphorylase activity       --
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  glycosyltransferase activity
   |__pentosyltransferase activity
       |__purine-nucleoside phosphorylase activity  5 rec.
           |__guanosine phosphorylase activity
           |__S-methyl-5-thioadenosine phosphorylase activity 2 rec.
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Is a pentosyltransferase activity
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Synonyms
  • "inosine phosphorylase activity" NARROW[ EC:2 ]
    "inosine-guanosine phosphorylase activity" RELATED[ EC:2 ]
    "PNPase activity" RELATED[ EC:2 ]
    "PUNPI" RELATED[ EC:2 ]
    "PUNPII" RELATED[ EC:2 ]
    "purine deoxynucleoside phosphorylase activity" RELATED[ EC:2 ]
    "purine deoxyribonucleoside phosphorylase activity" RELATED[ EC:2 ]
    "purine nucleoside phosphorylase activity" RELATED[ EC:2 ]
    "purine ribonucleoside phosphorylase activity" RELATED[ EC:2 ]
    "purine-nucleoside:phosphate ribosyltransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.4.2.1
MetaCyc:PNP-RXN
Reactome:R-HSA-112033 "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine"
Reactome:R-HSA-112034 "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine"
Reactome:R-HSA-74242 "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose"
Reactome:R-HSA-74249 "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose"
Reactome:R-HSA-9735775 "Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose"
Reactome:R-HSA-9735789 "Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose"
Reactome:R-HSA-9755044 "PNP trimer transforms RBV to T-CONH2"
RHEA:19805
RHEA:27638
RHEA:27642
RHEA:27646