FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term pyrroline-5-carboxylate reductase activity ID (Ontology) GO:0004735 (Gene Ontology)
Definition Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.[ EC:1 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 pyrroline-5-carboxylate reductase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | pyrroline-5-carboxylate reductase activity
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  oxidoreductase activity, acting on the CH-NH group of donors
   |__oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
       |__pyrroline-5-carboxylate reductase activity  2 rec.
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Is a oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
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Synonyms
  • "1-pyrroline-5-carboxylate reductase activity" RELATED[ EC:1 ]
    "L-proline oxidase activity" RELATED[ EC:1 ]
    "L-proline-NAD(P)+ 5-oxidoreductase activity" RELATED[ EC:1 ]
    "L-proline:NAD(P)+ 5-oxidoreductase activity" RELATED[ EC:1 ]
    "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" RELATED[ EC:1 ]
    "P5CR activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.5.1.2
MetaCyc:PYRROLINECARBREDUCT-RXN
Reactome:R-HSA-6783939 "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro"
Reactome:R-HSA-6783955 "PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro"
Reactome:R-HSA-70664 "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro"
RHEA:14109