FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term pyruvate dehydrogenase (acetyl-transferring) activity ID (Ontology) GO:0004739 (Gene Ontology)
Definition Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H+ = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.
Also Known As"pyruvate dehydrogenase (lipoamide) activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 pyruvate dehydrogenase (acetyl-transferring) activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | pyruvate dehydrogenase (acetyl-transferring) activity       --
     enables | pyruvate dehydrogenase (acetyl-transferring) activity       --
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  oxidoreductase activity, acting on the aldehyde or oxo group of donors
   |__oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
       |__pyruvate dehydrogenase (acetyl-transferring) activity  7 rec.
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Is a oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
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Synonyms
  • "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW[ EC:1 ]
    "PDH" RELATED[ EC:1 ]
    "pyruvate dehydrogenase (lipoamide) activity" EXACT
    "pyruvate dehydrogenase complex activity" RELATED[ EC:1 ]
    "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" RELATED[ EC:1 ]
    "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.2.4.1
MetaCyc:RXN0-1134
Reactome:R-HSA-9861734 "PDH E1 decarboxylates PYR, transferring acetyl to DLAT"
RHEA:19189