FB2026_03 , released September 17, 2026
CV Term Report
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Term all-trans-retinol dehydrogenase (NAD+) activity ID (Ontology) GO:0004745 (Gene Ontology)
Definition Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 all-trans-retinol dehydrogenase (NAD+) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | all-trans-retinol dehydrogenase (NAD+) activity       --
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  alcohol dehydrogenase [NAD(P)+] activity
   |__alcohol dehydrogenase (NAD+) activity
       |__all-trans-retinol dehydrogenase (NAD+) activity  4 rec.
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Is a alcohol dehydrogenase (NAD+) activity
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Synonyms
  • "all-trans retinol dehydrogenase activity" BROAD[ EC:1 ]
    "retinal reductase activity" BROAD[ PubMed:12036956 ]
    "retinene reductase activity" BROAD[ EC:1 ]
    "retinol (vitamin A1) dehydrogenase activity" BROAD[ EC:1 ]
    "retinol dehydrogenase activity" BROAD
Secondary IDs
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EC:1.1.1.105
MetaCyc:RETINOL-DEHYDROGENASE-RXN
Reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL"
Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA"
Reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL"
Reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro"
Reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL"
RHEA:21284
RHEA:48488