FB2026_03 , released September 17, 2026
CV Term Report
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Term ribose-5-phosphate isomerase activity ID (Ontology) GO:0004751 (Gene Ontology)
Definition Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate.
Also Known As"5-phosphoribose isomerase activity" ; "D-ribose 5-phosphate isomerase activity" ; "D-ribose-5-phosphate aldose-ketose-isomerase activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ribose-5-phosphate isomerase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | ribose-5-phosphate isomerase activity
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  intramolecular oxidoreductase activity
   |__intramolecular oxidoreductase activity, interconverting aldoses and ketoses
       |__ribose-5-phosphate isomerase activity  1 rec.
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Is a intramolecular oxidoreductase activity, interconverting aldoses and ketoses
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Synonyms
  • "5-phosphoribose isomerase activity" EXACT[ EC:5 ]
    "D-ribose 5-phosphate isomerase activity" EXACT[ EC:5 ]
    "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT[ EC:5 ]
    "D-ribose-5-phosphate ketol-isomerase activity" EXACT[ EC:5 ]
    "pentose phosphate isomerase (PPI)" EXACT
    "phosphopentoseisomerase activity" EXACT[ EC:5 ]
    "phosphopentosisomerase activity" EXACT[ EC:5 ]
    "phosphoriboisomerase activity" EXACT[ EC:5 ]
    "ribose 5-phosphate epimerase activity" EXACT[ EC:5 ]
    "ribose phosphate isomerase activity" EXACT[ EC:5 ]
Secondary IDs
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EC:5.3.1.6
KEGG_REACTION:R01056
MetaCyc:RIB5PISOM-RXN
Reactome:R-HSA-177784 "RPIA isomerizes ribose 5-phosphate to D-ribulose 5-phosphate"
Reactome:R-HSA-5660013 "Defective RPIA does not isomerize RU5P to R5P"
Reactome:R-HSA-5660015 "Defective RPIA does not isomerize R5P to RU5P"
Reactome:R-HSA-71306 "RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphate"
RHEA:14657