FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term sepiapterin reductase (NADP+) activity ID (Ontology) GO:0004757 (Gene Ontology)
Definition Catalysis of the reactions: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H+ + 2 NADPH.[ EC:1 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Genes
 sepiapterin reductase (NADP+) activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | sepiapterin reductase (NADP+) activity       2
Spanning Tree (Parents/Children)
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  oxidoreductase activity, acting on CH-OH group of donors
   |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
       |__sepiapterin reductase (NADP+) activity  2 rec.
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Is a oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Synonyms
  • "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.153
MetaCyc:SEPIAPTERIN-REDUCTASE-RXN
Reactome:R-HSA-1475414 "PTHP is reduced to BH4 by sepiapterin reductase (SPR)"
Reactome:R-HSA-1497869 "Salvage - Sepiapterin is reduced to q-BH2"
RHEA:18953
RHEA:32627