FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term sphingomyelin phosphodiesterase activity ID (Ontology) GO:0004767 (Gene Ontology)
Definition Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.[ EC:3 ]
Also Known As "sphingomyelinase activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       4
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 sphingomyelin phosphodiesterase activity (all annotations which use CV term, excluding "NOT" statements)       1      4
     enables | sphingomyelin phosphodiesterase activity       --       4
 NOT | enables | sphingomyelin phosphodiesterase activity       --       1
Spanning Tree (Parents/Children)
Only view relationship: 
phosphoric ester hydrolase activity
 |__phosphoric diester hydrolase activity__
phospholipase activity                     |
 |__sphingophospholipase activity__________|
                                           sphingomyelin phosphodiesterase activity  6 rec.
                                            |__acid sphingomyelin phosphodiesterase activity 3 rec.
                                            |__neutral sphingomyelin phosphodiesterase activity 1 rec.
                                            |__sphingomyelin phosphodiesterase D activity 1 rec.
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Is a phosphoric diester hydrolase activity
sphingophospholipase activity
Part of
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Synonyms
  • "sphingomyelin cholinephosphohydrolase activity" RELATED[ EC:3 ]
    "sphingomyelinase activity" EXACT
Secondary IDs
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EC:3.1.4.12
KEGG_REACTION:R02541
MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
Reactome:R-HSA-1605797 "SMPD1 hydrolyzes SPHM"
Reactome:R-HSA-1606273 "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)"
Reactome:R-HSA-1606288 "SMPD4 hydrolyzes sphingomyelin (ER membrane)"
Reactome:R-HSA-1640164 "ENPP7 hydrolyzes sphingomyelin"
Reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets"
RHEA:19253