FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term sphingomyelin phosphodiesterase activity ID (Ontology) GO:0004767 (Gene Ontology)
Definition Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.[ EC:3 ]
Also Known As"sphingomyelinase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 sphingomyelin phosphodiesterase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | sphingomyelin phosphodiesterase activity       --
 NOT | enables | sphingomyelin phosphodiesterase activity       --
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phosphoric ester hydrolase activity
 |__phosphoric diester hydrolase activity__
phospholipase activity                     |
 |__sphingophospholipase activity__________|
                                           sphingomyelin phosphodiesterase activity  6 rec.
                                            |__acid sphingomyelin phosphodiesterase activity 3 rec.
                                            |__neutral sphingomyelin phosphodiesterase activity 1 rec.
                                            |__sphingomyelin phosphodiesterase D activity 1 rec.
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Is a phosphoric diester hydrolase activity
sphingophospholipase activity
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Synonyms
  • "sphingomyelin cholinephosphohydrolase activity" RELATED[ EC:3 ]
    "sphingomyelinase activity" EXACT
Secondary IDs
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EC:3.1.4.12
KEGG_REACTION:R02541
MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
Reactome:R-HSA-1605797 "SMPD1 hydrolyzes SPHM"
Reactome:R-HSA-1606273 "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)"
Reactome:R-HSA-1606288 "SMPD4 hydrolyzes sphingomyelin (ER membrane)"
Reactome:R-HSA-1640164 "ENPP7 hydrolyzes sphingomyelin"
Reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets"
RHEA:19253
RHEA:45324
RHEA:54284