FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term isoleucine-tRNA ligase activity ID (Ontology) GO:0004822 (Gene Ontology)
Definition Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+.[ EC:6 ]
Also Known As"isoleucyl-tRNA synthetase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 isoleucine-tRNA ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | isoleucine-tRNA ligase activity
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ligase activity, forming carbon-oxygen bonds__
catalytic activity, acting on a tRNA__________|
                                              aminoacyl-tRNA ligase activity
                                               |__isoleucine-tRNA ligase activity  2 rec.
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Is a aminoacyl-tRNA ligase activity
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Synonyms
  • "isoleucine translase activity" RELATED[ EC:6 ]
    "isoleucine-transfer RNA ligase activity" RELATED[ EC:6 ]
    "isoleucine-tRNA synthetase activity" RELATED[ EC:6 ]
    "isoleucyl-transfer ribonucleate synthetase activity" RELATED[ EC:6 ]
    "isoleucyl-transfer RNA synthetase activity" RELATED[ EC:6 ]
    "isoleucyl-tRNA synthetase activity" EXACT
    "L-isoleucine:tRNAIle ligase (AMP-forming)" RELATED[ EC:6 ]
Secondary IDs
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EC:6.1.1.5
KEGG_REACTION:R03656
MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN
Reactome:R-HSA-379893 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate"
Reactome:R-HSA-380176 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate"
RHEA:11060