FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term leucine-tRNA ligase activity ID (Ontology) GO:0004823 (Gene Ontology)
Definition Catalysis of the reaction: leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu).
Also Known As"leucyl-tRNA synthetase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 leucine-tRNA ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | leucine-tRNA ligase activity
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ligase activity, forming carbon-oxygen bonds__
catalytic activity, acting on a tRNA__________|
                                              aminoacyl-tRNA ligase activity
                                               |__leucine-tRNA ligase activity  2 rec.
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Is a aminoacyl-tRNA ligase activity
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Synonyms
  • "leucine translase activity" RELATED[ EC:6 ]
    "leucine-tRNA synthetase activity" RELATED[ EC:6 ]
    "leucine:tRNALeu ligase (AMP-forming)" RELATED[ EC:6 ]
    "leucyl-transfer ribonucleate synthetase activity" RELATED[ EC:6 ]
    "leucyl-transfer ribonucleic acid synthetase activity" RELATED[ EC:6 ]
    "leucyl-transfer RNA synthetase activity" RELATED[ EC:6 ]
    "leucyl-tRNA synthetase activity" EXACT
Secondary IDs
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EC:6.1.1.4
KEGG_REACTION:R03657
MetaCyc:LEUCINE--TRNA-LIGASE-RXN
Reactome:R-HSA-379974 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate"
Reactome:R-HSA-380200 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate"
RHEA:11688