FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term proline-tRNA ligase activity ID (Ontology) GO:0004827 (Gene Ontology)
Definition Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).[ EC:6 ]
Also Known As"prolyl-tRNA synthetase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 proline-tRNA ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | proline-tRNA ligase activity
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ligase activity, forming carbon-oxygen bonds__
catalytic activity, acting on a tRNA__________|
                                              aminoacyl-tRNA ligase activity
                                               |__proline-tRNA ligase activity  2 rec.
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Is a aminoacyl-tRNA ligase activity
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Synonyms
  • "L-proline:tRNAPro ligase (AMP-forming)" RELATED[ EC:6 ]
    "proline translase activity" RELATED[ EC:6 ]
    "prolinyl-tRNA ligase activity" RELATED[ EC:6 ]
    "prolyl-s-RNA synthetase activity" RELATED[ EC:6 ]
    "prolyl-transfer ribonucleate synthetase activity" RELATED[ EC:6 ]
    "prolyl-transfer ribonucleic acid synthetase activity" RELATED[ EC:6 ]
    "prolyl-transferRNA synthetase activity" RELATED[ EC:6 ]
    "prolyl-tRNA synthetase activity" EXACT
Secondary IDs
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EC:6.1.1.15
MetaCyc:PROLINE--TRNA-LIGASE-RXN
Reactome:R-HSA-379865 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate"
Reactome:R-HSA-380198 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate"
RHEA:14305