FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term serine-tRNA ligase activity ID (Ontology) GO:0004828 (Gene Ontology)
Definition Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). Also catalyzes the formation of L-seryl-tRNA(Sec) from tRNA(Sec), the special tRNA for selenocysteine.[ EC:6 ]
Also Known As"seryl-tRNA synthetase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 serine-tRNA ligase activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | serine-tRNA ligase activity
     enables | serine-tRNA ligase activity
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ligase activity, forming carbon-oxygen bonds__
catalytic activity, acting on a tRNA__________|
                                              aminoacyl-tRNA ligase activity
                                               |__serine-tRNA ligase activity  3 rec.
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Is a aminoacyl-tRNA ligase activity
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Synonyms
  • "L-serine:tRNASer ligase (AMP-forming)" RELATED[ EC:6 ]
    "serine translase activity" RELATED[ EC:6 ]
    "SerRS activity" RELATED[ EC:6 ]
    "seryl-transfer ribonucleate synthetase activity" RELATED[ EC:6 ]
    "seryl-transfer ribonucleic acid synthetase activity" RELATED[ EC:6 ]
    "seryl-transfer RNA synthetase activity" RELATED[ EC:6 ]
    "seryl-tRNA synthetase activity" EXACT
Secondary IDs
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EC:6.1.1.11
MetaCyc:SERINE--TRNA-LIGASE-RXN
Reactome:R-HSA-379992 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate"
Reactome:R-HSA-380239 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate"
RHEA:12292
RHEA:42580