FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term tryptophan-tRNA ligase activity ID (Ontology) GO:0004830 (Gene Ontology)
Definition Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).[ EC:6 ]
Also Known As"tryptophanyl-tRNA synthetase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 tryptophan-tRNA ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | tryptophan-tRNA ligase activity
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ligase activity, forming carbon-oxygen bonds__
catalytic activity, acting on a tRNA__________|
                                              aminoacyl-tRNA ligase activity
                                               |__tryptophan-tRNA ligase activity  2 rec.
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Is a aminoacyl-tRNA ligase activity
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Synonyms
  • "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" RELATED[ EC:6 ]
    "L-tryptophan-tRNATrp ligase (AMP-forming)" RELATED[ EC:6 ]
    "L-tryptophan:tRNATrp ligase (AMP-forming)" RELATED[ EC:6 ]
    "TrpRS activity" RELATED[ EC:6 ]
    "tryptophan translase activity" RELATED[ EC:6 ]
    "tryptophanyl ribonucleic synthetase activity" RELATED[ EC:6 ]
    "tryptophanyl-transfer ribonucleate synthetase activity" RELATED[ EC:6 ]
    "tryptophanyl-transfer ribonucleic acid synthetase activity" RELATED[ EC:6 ]
    "tryptophanyl-transfer ribonucleic synthetase activity" RELATED[ EC:6 ]
    "tryptophanyl-transfer RNA synthetase activity" RELATED[ EC:6 ]
    "tryptophanyl-tRNA synthase activity" RELATED[ EC:6 ]
    "tryptophanyl-tRNA synthetase activity" EXACT
Secondary IDs
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EC:6.1.1.2
MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN
Reactome:R-HSA-379977 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate"
Reactome:R-HSA-380222 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate"
RHEA:24080