FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term L-tryptophan 2,3-dioxygenase activity ID (Ontology) GO:0004833 (Gene Ontology)
Definition Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.[ EC:1 ]
Also Known As"indoleamine-pyrrole 2,3-dioxygenase activity" ; "tryptophan 2,3-dioxygenase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 L-tryptophan 2,3-dioxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | L-tryptophan 2,3-dioxygenase activity
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oxidoreductase activity, acting on single donors with incorporation of molecular oxygen__
dioxygenase activity_____________________________________________________________________|
                                                                                         oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
                                                                                          |__L-tryptophan 2,3-dioxygenase activity  1 rec.
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Is a oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
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Synonyms
  • "indolamine 2,3-dioxygenase activity" BROAD[ EC:1 ]
    "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT
    "L-tryptophan pyrrolase activity" RELATED[ EC:1 ]
    "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" RELATED[ EC:1 ]
    "TDO" RELATED[ EC:1 ]
    "tryptamin 2,3-dioxygenase activity" RELATED[ EC:1 ]
    "tryptamine 2,3-dioxygenase activity" RELATED[ EC:1 ]
    "tryptophan 2,3-dioxygenase activity" EXACT
    "tryptophan oxygenase activity" BROAD[ EC:1 ]
    "tryptophan peroxidase activity" BROAD[ EC:1 ]
    "tryptophan pyrrolase activity" BROAD[ EC:1 ]
Secondary IDs
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EC:1.13.11.11
MetaCyc:RXN-8665
Reactome:R-HSA-198563 "IDO1 dioxygenates L-Trp to NFK"
Reactome:R-HSA-71188 "TDO tetramer dioxygenates L-Trp to NFK"
Reactome:R-HSA-888614 "IDO2 dioxygenates L-Trp to NFK"
RHEA:24536