FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term ubiquitin activating enzyme activity ID (Ontology) GO:0004839 (Gene Ontology)
Definition Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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Relevant FlyBase reports
 Gene Groups Genes
 ubiquitin activating enzyme activity (all annotations which use CV term, excluding "NOT" statements)       1      2
     enables | ubiquitin activating enzyme activity       --       2
Spanning Tree (Parents/Children)
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ligase activity, forming carbon-sulfur bonds__
catalytic activity, acting on a protein_______|
ATP-dependent activity________________________|
                                              ubiquitin-like modifier activating enzyme activity
                                               |__ubiquitin activating enzyme activity  3 rec.
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Is a ubiquitin-like modifier activating enzyme activity
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Synonyms
  • "E1 ubiquitin-activating enzyme" RELATED[ EC:6 ]
Secondary IDs
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EC:6.2.1.45
Reactome:R-HSA-8852132 "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol"
Reactome:R-HSA-8852133 "UBA1 conjugates ubiquitin to UBA1 in the cytosol"
Reactome:R-HSA-8852134 "UBA1 adenylates ubiquitin in the cytosol"
Reactome:R-HSA-8865050 "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol"
Reactome:R-HSA-8865090 "UBA6 adenylates ubiquitin in the cytosol"
Reactome:R-HSA-8865098 "UBA6 conjugates ubiquitin to UBA6 in the cytosol"