FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term cysteine-type deubiquitinase activity ID (Ontology) GO:0004843 (Gene Ontology)
Definition An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.[ PubMed:30783221 ]
Also Known As"thiol-dependent deubiquitinase" ; "thiol-dependent ubiquitin-specific protease activity" ; "thiol-dependent ubiquitinyl hydrolase activity"
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Annotations
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Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 cysteine-type deubiquitinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | cysteine-type deubiquitinase activity       --
 NOT | enables | cysteine-type deubiquitinase activity       --
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peptidase activity
 |__cysteine-type peptidase activity_______
ubiquitin-like protein peptidase activity  |
 |__deubiquitinase activity________________|
                                           cysteine-type deubiquitinase activity  47 rec.
                                            |__Met1-linked polyubiquitin deubiquitinase activity 1 rec.
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Is a cysteine-type peptidase activity
deubiquitinase activity
Part of
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Synonyms
  • "deubiquitinase" BROAD[ PubMed:19261746 ]
    "deubiquitinase activity" BROAD
    "deubiquitinating enzyme" BROAD[ PubMed:19188440 ]
    "deubiquitylase" BROAD[ PubMed:15657442 ]
    "thiol-dependent deubiquitinase" EXACT
    "thiol-dependent ubiquitin-specific protease activity" EXACT
    "thiol-dependent ubiquitinyl hydrolase activity" EXACT
    "ubiquitin C-terminal hydrolase" RELATED[ EC:3 ]
    "ubiquitin hydrolase activity" BROAD
    "ubiquitin-specific protease activity" BROAD
    "ubiquitinyl hydrolase 1 activity" NARROW
    "ubiquitinyl hydrolase activity" BROAD
    "UBP" NARROW
    "UCH2" NARROW
Secondary IDs
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EC:3.4.19.12
Reactome:R-HSA-1358795 "Deubiquitination of RNF41 by P-USP8"
Reactome:R-HSA-2179291 "UCHL5, USP15 deubiquitinate TGFBR1"
Reactome:R-HSA-3215295 "USP7 deubiquitinates MDM2"
Reactome:R-HSA-3215310 "USP7 deubiquitinates TP53 and counteracts MDM2"
Reactome:R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2"
Reactome:R-HSA-4641236 "USP8 deubiquitinates FZD to potentiate WNT signaling"
Reactome:R-HSA-5653770 "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA"
Reactome:R-HSA-5655466 "USP1:WDR48 deubiquitinates monoUb:K164-PCNA"
Reactome:R-HSA-5688797 "ATXN3 family cleave Ub chains"
Reactome:R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2"
Reactome:R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN"
Reactome:R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4"
Reactome:R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53"
Reactome:R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B"
Reactome:R-HSA-5690152 "USP5 cleaves polyubiquitin"
Reactome:R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A"
Reactome:R-HSA-5690159 "USP21 deubiquitinates RIPK1,DDX58"
Reactome:R-HSA-5690196 "USP8 deubiquitinates RNF128"
Reactome:R-HSA-5690319 "UCHL1, UCHL3 cleave ubiquitin adducts"
Reactome:R-HSA-5690759 "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1"
Reactome:R-HSA-5690790 "Histone H2A is dubiquitinated by the PR-DUB complex"
Reactome:R-HSA-5691381 "MYSM1 deubiquitinates Histone H2A"
Reactome:R-HSA-5696465 "USP45 deubiquitinates ERCC1"
Reactome:R-HSA-5696534 "USP18 deubiquitinates TAK1:TAB1"
Reactome:R-HSA-5696564 "USP25 deubiquitinates DDX58"
Reactome:R-HSA-5696600 "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1"
Reactome:R-HSA-5696605 "USP12, USP26 deubiquitinate AR"
Reactome:R-HSA-5696627 "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG"
Reactome:R-HSA-5696872 "USP30 deubiquitinates Ub-MOM proteins"
Reactome:R-HSA-5696914 "USP28 deubiquitinates CLSPN and MYC"
Reactome:R-HSA-5696945 "USP33 deubiquitinates CCP110,ARRB"
Reactome:R-HSA-5696947 "USP47 deubiquitinates POLB"
Reactome:R-HSA-5696958 "USP44 deubiquitinates CDC20"
Reactome:R-HSA-5696960 "USP49 deubiquitinates H2B"
Reactome:R-HSA-5696968 "USP20, USP33 deubiquitinate ADRB2"
Reactome:R-HSA-5696997 "USP24 deubiquitinates DDB2"
Reactome:R-HSA-5697009 "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2"
Reactome:R-HSA-6781764 "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1"
Reactome:R-HSA-6781779 "USP13 deubiquitinates BECN1,USP10"
Reactome:R-HSA-6781814 "USP19 deubiquitinates RNF123"
Reactome:R-HSA-6781897 "USP11 deubiquitinates NFKBIA"
Reactome:R-HSA-6782069 "UVSSA:USP7 deubiquitinates ERCC6"
Reactome:R-HSA-6782106 "USP10 deubiquitinates SNX3, CFTR"
Reactome:R-HSA-6782628 "USP8 deubiquitinates STAM2:HGS"
Reactome:R-HSA-6782820 "USP17 deubiquitinates SUDS3"
Reactome:R-HSA-6783177 "USP21 deubiquitinates GATA3,IL33"
Reactome:R-HSA-6786171 "FANCD2 deubiquitination by USP1:WDR48"
Reactome:R-HSA-6807118 "USP7 deubiquitinates monoubiquitinated PTEN"
Reactome:R-HSA-6807206 "USP13 and OTUD3 deubiquitinate PTEN"
Reactome:R-HSA-870437 "USP9X (FAM) deubiquitinates SMAD4"
Reactome:R-HSA-8853503 "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin"
Reactome:R-HSA-8853514 "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin"
Reactome:R-HSA-8853515 "OTULIN,USP5 cleaves UBC yielding ubiquitin"
Reactome:R-HSA-8853529 "OTULIN,USP5 cleaves UBB yielding ubiquitin"
Reactome:R-HSA-8862184 "USP48 cleaves polyubiquitin"
Reactome:R-HSA-8865182 "OTUD7A hydrolyses K11diUb"
Reactome:R-HSA-8869456 "USP4 deubiquitinate TRAF2,TRAF6"
Reactome:R-HSA-8873946 "OTUD3 deubiquitinates PTEN"
Reactome:R-HSA-8875443 "USP8 deubiquitinates LRIG1"
Reactome:R-HSA-8986083 "USP33 deubiquitinates ROBO1"
Reactome:R-HSA-9033478 "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin"
Reactome:R-HSA-9033491 "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin"
Reactome:R-HSA-9653514 "USP17L2 deubiquitinates RCE1"