FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

uracil DNA N-glycosylase activity

ID (Ontology)

GO:0004844 (Gene Ontology)

Definition

Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.[ PubMed:9224623 ]

Also Known As

"uracil-DNA glycosylase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
uracil DNA N-glycosylase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| uracil DNA N-glycosylase activity
NOT \| enables \| uracil DNA N-glycosylase activity

Spanning Tree (Parents/Children)

  DNA N-glycosylase activity
   |__deaminated base DNA N-glycosylase activity
       |__uracil DNA N-glycosylase activity  2 rec.
           |__G/U mismatch-specific uracil-DNA glycosylase activity 1 rec.
           |__single-strand selective uracil DNA N-glycosylase activity 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	deaminated base DNA N-glycosylase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"uracil-DNA glycosylase activity" EXACT
Secondary IDs

External Crossreferences & Linkouts
	EC:3.2.2.27 Reactome:R-HSA-110215 "Cleavage of uracil by UNG glycosylase" Reactome:R-HSA-110217 "Cleavage of 5-hydroxyluracil by UNG glycosylase" Reactome:R-HSA-9817512 "UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3"