FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term uracil DNA N-glycosylase activity ID (Ontology) GO:0004844 (Gene Ontology)
Definition Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.[ PubMed:9224623 ]
Also Known As "uracil-DNA glycosylase activity"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 uracil DNA N-glycosylase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | uracil DNA N-glycosylase activity       2
 NOT | enables | uracil DNA N-glycosylase activity       1
Spanning Tree (Parents/Children)
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  DNA N-glycosylase activity
   |__deaminated base DNA N-glycosylase activity
       |__uracil DNA N-glycosylase activity  2 rec.
           |__G/U mismatch-specific uracil-DNA glycosylase activity 1 rec.
           |__single-strand selective uracil DNA N-glycosylase activity 1 rec.
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Is a deaminated base DNA N-glycosylase activity
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Synonyms
  • "uracil-DNA glycosylase activity" EXACT
Secondary IDs
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EC:3.2.2.27
Reactome:R-HSA-110215 "Cleavage of uracil by UNG glycosylase"
Reactome:R-HSA-110217 "Cleavage of 5-hydroxyluracil by UNG glycosylase"
Reactome:R-HSA-9817512 "UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3"