FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term uroporphyrinogen-III synthase activity ID (Ontology) GO:0004852 (Gene Ontology)
Definition Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III.[ EC:4 ]
Comment
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Genes
 uroporphyrinogen-III synthase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | uroporphyrinogen-III synthase activity       2
Spanning Tree (Parents/Children)
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  carbon-oxygen lyase activity
   |__hydro-lyase activity
       |__uroporphyrinogen-III synthase activity  2 rec.
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Is a hydro-lyase activity
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Synonyms
  • "hydroxymethylbilane hydro-lyase (cyclizing) activity" RELATED[ EC:4 ]
    "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" RELATED[ EC:4 ]
    "porphobilinogenase activity" RELATED[ EC:4 ]
    "URO-synthase activity" RELATED[ EC:4 ]
    "uroporphyrinogen III cosynthase activity" RELATED[ EC:4 ]
    "uroporphyrinogen isomerase activity" RELATED[ EC:4 ]
    "uroporphyrinogen-III cosynthase activity" RELATED[ EC:4 ]
    "uroporphyrinogen-III cosynthetase activity" RELATED[ EC:4 ]
Secondary IDs
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EC:4.2.1.75
KEGG_REACTION:R03165
MetaCyc:UROGENIIISYN-RXN
Reactome:R-HSA-189488 "UROS transforms HMB to URO3"
RHEA:18965