FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term nuclear receptor activity ID (Ontology) GO:0004879 (Gene Ontology)
Definition A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.[ PubMed:23457262 ]
Also Known As "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" ; "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      23
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 nuclear receptor activity (all annotations which use CV term, excluding "NOT" statements)      23
     contributes_to | nuclear receptor activity       2
     enables | nuclear receptor activity      23
Spanning Tree (Parents/Children)
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DNA-binding transcription factor activity
 |__DNA-binding transcription factor activity, RNA polymerase II-specific__
 |__ligand-modulated transcription factor activity_________________________|
molecular transducer activity                                              |
 |__signaling receptor activity____________________________________________|
                                                                           nuclear receptor activity  23 rec.
                                                                            |__bile acid nuclear receptor activity
                                                                            |__nuclear steroid receptor activity 4 rec.
                                                                                |__nuclear estrogen receptor activity
                                                                                |__nuclear glucocorticoid receptor activity(+)
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Is a DNA-binding transcription factor activity, RNA polymerase II-specific
signaling receptor activity
ligand-modulated transcription factor activity
Part of
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Synonyms
  • "1,25-(OH)2D3 receptor activity" NARROW
    "9-cis retinoic acid receptor activity" NARROW
    "androgen receptor activity" NARROW
    "calcitriol receptor activity" NARROW
    "ecdysteroid hormone receptor activity" NARROW
    "estrogen nuclear receptor activity" NARROW
    "glucocorticoid receptor activity" NARROW
    "juvenile hormone receptor activity" NARROW
    "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT
    "ligand-dependent nuclear receptor activity" RELATED
    "ligand-dependent transcription factor activity" RELATED
    "nuclear hormone receptor" NARROW
    "retinoic acid receptor activity" NARROW
    "retinoid-X receptor activity" NARROW
    "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding" NARROW
    "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding" NARROW
    "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding" EXACT
    "RXR" NARROW
    "thyroid hormone receptor activity" NARROW
    "vitamin A receptor activity" NARROW
    "vitamin D receptor activity" NARROW
    "vitamin D3 receptor activity" NARROW
Secondary IDs
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Reactome:R-HSA-400143 "Fatty acid ligands activate PPARA"
Reactome:R-HSA-8936849 "AHR:2xHSP90:AIP:PTGES3 binds TCDD"
Reactome:R-HSA-8937169 "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm"
Reactome:R-HSA-8937191 "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates"