FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term excitatory extracellular ligand-gated monoatomic ion channel activity ID (Ontology) GO:0005231 (Gene Ontology)
Definition Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential.[ ISBN:0323037070 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       8
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Relevant FlyBase reports
 Genes
 excitatory extracellular ligand-gated monoatomic ion channel activity (all annotations which use CV term, excluding "NOT" statements)       8
     enables | excitatory extracellular ligand-gated monoatomic ion channel activity       8
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  ligand-gated monoatomic ion channel activity
   |__extracellular ligand-gated monoatomic ion channel activity
       |__excitatory extracellular ligand-gated monoatomic ion channel activity  22 rec.
           |__acetylcholine-gated monoatomic cation-selective channel activity 12 rec.
           |__extracellularly ATP-gated monoatomic cation channel activity
           |__extracellularly glutamate-gated ion channel activity 2 rec.
           |   |__extracellularly glutamate-gated chloride channel activity 2 rec.
           |__extracellularly glycine-gated ion channel activity 1 rec.
               |__extracellularly glycine-gated chloride channel activity
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Is a extracellular ligand-gated monoatomic ion channel activity
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Reactome:R-HSA-399711 "Activation of Ca impermeable AMPA receptors"
Reactome:R-HSA-399712 "Activation of Ca permeable AMPA receptors"
Reactome:R-HSA-420980 "Activation of Ca permeable AMPA receptors"
Reactome:R-HSA-432164 "Ca2+ influx into the post-synaptic cell"
Reactome:R-HSA-438037 "Membrane depolarization upon activation of Ca impermeable AMPA receptors"