FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

excitatory extracellular ligand-gated monoatomic ion channel activity

ID (Ontology)

GO:0005231 (Gene Ontology)

Definition

Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential.[ ISBN:0323037070 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
excitatory extracellular ligand-gated monoatomic ion channel activity (all annotations which use CV term, excluding "NOT" statements)
enables \| excitatory extracellular ligand-gated monoatomic ion channel activity

Spanning Tree (Parents/Children)

  ligand-gated monoatomic ion channel activity
   |__extracellular ligand-gated monoatomic ion channel activity
       |__excitatory extracellular ligand-gated monoatomic ion channel activity  22 rec.
           |__acetylcholine-gated monoatomic cation-selective channel activity 12 rec.
           |__extracellularly ATP-gated monoatomic cation channel activity
           |__extracellularly glutamate-gated ion channel activity 2 rec.
           |   |__extracellularly glutamate-gated chloride channel activity 2 rec.
           |__extracellularly glycine-gated ion channel activity 1 rec.
               |__extracellularly glycine-gated chloride channel activity

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	extracellular ligand-gated monoatomic ion channel activity
Part of
Synonyms & Secondary IDs
Synonyms

Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-399711 "Activation of Ca impermeable AMPA receptors" Reactome:R-HSA-399712 "Activation of Ca permeable AMPA receptors" Reactome:R-HSA-420980 "Activation of Ca permeable AMPA receptors" Reactome:R-HSA-432164 "Ca2+ influx into the post-synaptic cell" Reactome:R-HSA-438037 "Membrane depolarization upon activation of Ca impermeable AMPA receptors"