FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term inward rectifier potassium channel activity ID (Ontology) GO:0005242 (Gene Ontology)
Definition Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.[ PubMed:14977398 ]
Also Known As "Kir channel activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       4
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 inward rectifier potassium channel activity (all annotations which use CV term, excluding "NOT" statements)       1      4
     contributes_to | inward rectifier potassium channel activity       --       1
     enables | inward rectifier potassium channel activity       --       4
Spanning Tree (Parents/Children)
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monoatomic cation channel activity
 |__ligand-gated monoatomic cation channel activity__
potassium channel activity                           |
 |__voltage-gated potassium channel activity_________|
ligand-gated monoatomic ion channel activity         |
 |__ligand-gated monoatomic cation channel activity__|
voltage-gated monoatomic cation channel activity     |
 |__voltage-gated potassium channel activity_________|
                                                     inward rectifier potassium channel activity  5 rec.
                                                      |__ATP-activated inward rectifier potassium channel activity
                                                      |__G-protein activated inward rectifier potassium channel activity
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Is a voltage-gated potassium channel activity
ligand-gated monoatomic cation channel activity
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Synonyms
  • "Kir channel activity" EXACT
Secondary IDs
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Reactome:R-HSA-1296045 "Activation of Potassium transport channels"
Reactome:R-HSA-1296046 "KCNJs transport K+ from the extracellular region to cytosol"
Reactome:R-HSA-1369017 "Activation of ATP sensitive Potassium channels in muscle cells"
Reactome:R-HSA-5678261 "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol"
Reactome:R-HSA-5678418 "Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol"
Reactome:R-HSA-9729870 "KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol"
Reactome:R-HSA-9730521 "SARS-CoV-2 3a induces potassium efflux"
Reactome:R-HSA-9731072 "SARS-CoV-1 3a tetramer induces potassium efflux"