FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term chloride channel activity ID (Ontology) GO:0005254 (Gene Ontology)
Definition Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel.[ ISBN:0815340729 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 chloride channel activity (all annotations which use CV term, excluding "NOT" statements)
     enables | chloride channel activity       --
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monoatomic ion channel activity
 |__monoatomic anion channel activity________________
monoatomic anion transmembrane transporter activity  |
 |__monoatomic anion channel activity________________|
 |__chloride transmembrane transporter activity______|
                                                     chloride channel activity  38 rec.
                                                      |__extracellularly glutamate-gated chloride channel activity 2 rec.
                                                      |__extracellularly glycine-gated chloride channel activity
                                                      |__GABA-gated chloride ion channel activity 4 rec.
                                                      |__glycine-gated chloride ion channel activity 3 rec.
                                                      |__histamine-gated chloride channel activity 3 rec.
                                                      |__intracellularly ATP-gated chloride channel activity
                                                      |__intracellularly calcium-gated chloride channel activity 8 rec.
                                                      |__pH-gated chloride channel activity 6 rec.
                                                      |__serotonin-gated chloride channel activity
                                                      |__voltage-gated chloride channel activity 3 rec.
                                                      |   |__organellar voltage-gated chloride channel activity
                                                      |__volume-sensitive chloride channel activity 3 rec.
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Is a monoatomic anion channel activity
chloride transmembrane transporter activity
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Reactome:R-HSA-2684901 "ANOs transport cytosolic Cl- to extracellular region"
Reactome:R-HSA-2744242 "TTYH2/3 transport cytosolic Cl- to extracellular region"
Reactome:R-HSA-2744349 "TTYH1 transports cytosolic Cl- to extracellular region"
Reactome:R-HSA-2744361 "BESTs transport cytosolic Cl- to extracellular region"
Reactome:R-HSA-427570 "Group 3 - Selective Cl- transport"
Reactome:R-HSA-9659568 "ANO1 transports cytosolic Cl- to extracellular region"
Reactome:R-HSA-9712204 "ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region"
Reactome:R-HSA-975340 "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol"
Reactome:R-HSA-975449 "GABRR pentamers:GABA transports extracellular Cl- to cytosol"