FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term gamma-aminobutyric acid:sodium:chloride symporter activity ID (Ontology) GO:0005332 (Gene Ontology)
Definition Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in).[ PubMed:7589472 PubMed:7861179 ]
Also Known As"4-aminobutanoate:sodium symporter activity" ; "4-aminobutyrate:sodium symporter activity" ; "betaine/GABA:sodium symporter activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 gamma-aminobutyric acid:sodium:chloride symporter activity (all annotations which use CV term, excluding "NOT" statements)
     enables | gamma-aminobutyric acid:sodium:chloride symporter activity
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amino acid:monoatomic cation symporter activity
 |__amino acid:sodium symporter activity_________________________________
amino acid transmembrane transporter activity                            |
 |__gamma-aminobutyric acid transmembrane transporter activity___________|
secondary active transmembrane transporter activity                      |
 |__secondary active monocarboxylate transmembrane transporter activity__|
solute:sodium symporter activity                                         |
 |__amino acid:sodium symporter activity_________________________________|
 |__organic acid:sodium symporter activity_______________________________|
monoatomic anion:sodium symporter activity                               |
 |__sodium:chloride symporter activity___________________________________|
chloride:monoatomic cation symporter activity                            |
 |__sodium:chloride symporter activity___________________________________|
carboxylic acid transmembrane transporter activity                       |
 |__gamma-aminobutyric acid transmembrane transporter activity___________|
 |__secondary active monocarboxylate transmembrane transporter activity__|
                                                                         gamma-aminobutyric acid:sodium:chloride symporter activity  1 rec.
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Is a amino acid:sodium symporter activity
organic acid:sodium symporter activity
gamma-aminobutyric acid transmembrane transporter activity
secondary active monocarboxylate transmembrane transporter activity
sodium:chloride symporter activity
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Synonyms
  • "4-aminobutanoate:sodium symporter activity" EXACT
    "4-aminobutyrate:sodium symporter activity" EXACT
    "betaine/GABA:sodium symporter activity" EXACT
    "GABA:sodium symporter activity" EXACT
    "gamma-aminobutyric acid:sodium symporter activity" EXACT
    "sodium/chloride-dependent GABA transporter activity" BROAD
Secondary IDs
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Reactome:R-HSA-444007 "GAT1-3 mediate Na+/Cl- dependent GABA transport"
RHEA:70687
RHEA:70731
TC:2.A.22.3.2