FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term zinc ion transmembrane transporter activity ID (Ontology) GO:0005385 (Gene Ontology)
Definition Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 zinc ion transmembrane transporter activity (all annotations which use CV term, excluding "NOT" statements)
     enables | zinc ion transmembrane transporter activity       --
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  metal ion transmembrane transporter activity
   |__transition metal ion transmembrane transporter activity
       |__zinc ion transmembrane transporter activity  19 rec.
           |__ABC-type zinc transporter activity
           |__high-affinity zinc transmembrane transporter activity
           |__low-affinity zinc ion transmembrane transporter activity
           |__P-type zinc transporter activity
           |__zinc efflux transmembrane transporter activity 3 rec.
           |__zinc:bicarbonate symporter activity
           |   |__zinc:bicarbonate:selenite symporter activity
           |__zinc:proton antiporter activity
               |__zinc efflux antiporter activity
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Is a transition metal ion transmembrane transporter activity
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Synonyms
  • "cobalt, zinc uptake permease activity" RELATED
    "zinc, cadmium uptake permease activity" RELATED
    "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED
    "zinc, iron permease activity" NARROW
Secondary IDs
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MetaCyc:RXN0-12
Reactome:R-HSA-435366 "ZnT1 mediates the efflux of zinc from the cell"
Reactome:R-HSA-435375 "ZnT2 facilitates zinc vesicular sequestration"
Reactome:R-HSA-437084 "ZnT3 transports zinc into synaptic vesicles"
Reactome:R-HSA-437085 "ZnT5 transports zinc into secretory granules in pancreatic beta cells"
Reactome:R-HSA-437136 "SLC30A8 transports Zn2+ from cytosol to secretory granule"
Reactome:R-HSA-437139 "ZnT8 transports zinc into the Golgi apparatus"
Reactome:R-HSA-442317 "ZIP6 and ZIP14 mediate zinc influx into cells"
Reactome:R-HSA-442345 "hZIP10 mediates zinc influx into cells"
Reactome:R-HSA-442387 "ZIP8 mediates zinc influx into cells"
Reactome:R-HSA-442393 "ZIP7 mediates zinc efflux from the endoplasmic reticulum"
Reactome:R-HSA-442405 "hZIP5 mediates zinc uptake by cells"
Reactome:R-HSA-442422 "SLC39A1-4 transports Zn2+ from extracellular region to cytosol"
Reactome:R-HSA-5654125 "Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol"
Reactome:R-HSA-9820566 "ZnT5 transports zinc into the golgi apparatus"
Reactome:R-HSA-9928035 "ZnuABC transports Zn2+ to cytosol"