FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term P-type calcium transporter activity ID (Ontology) GO:0005388 (Gene Ontology)
Definition Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out).
Also Known As"ATP-dependent calcium transmembrane transporter activity" ; "calcium transmembrane transporter activity, phosphorylative mechanism" ; "calcium transporting ATPase activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 P-type calcium transporter activity (all annotations which use CV term, excluding "NOT" statements)
     enables | P-type calcium transporter activity       --
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monoatomic cation transmembrane transporter activity
 |__ATPase-coupled monoatomic cation transmembrane transporter activity__
active monoatomic ion transmembrane transporter activity                 |
 |__ATPase-coupled monoatomic cation transmembrane transporter activity__|
ATPase-coupled transmembrane transporter activity                        |
 |__ATPase-coupled monoatomic cation transmembrane transporter activity__|
metal ion transmembrane transporter activity                             |
 |__calcium ion transmembrane transporter activity_______________________|
P-type transmembrane transporter activity                                |
 |__P-type ion transporter activity______________________________________|
                                                                         P-type calcium transporter activity  5 rec.
                                                                          |__P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
                                                                          |__P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
                                                                          |__P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
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Is a calcium ion transmembrane transporter activity
P-type ion transporter activity
ATPase-coupled monoatomic cation transmembrane transporter activity
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Synonyms
  • "ATP-dependent calcium transmembrane transporter activity" EXACT
    "ATPase-coupled calcium transmembrane transporter activity" RELATED
    "Ca(2+)-transporting ATPase activity" RELATED[ EC:7 ]
    "Ca2+-transporting ATPase activity" RELATED[ EC:7 ]
    "calcium efflux ATPase" NARROW
    "calcium pump" BROAD
    "calcium transmembrane transporter activity, phosphorylative mechanism" EXACT
    "calcium transporting ATPase activity" EXACT
    "calcium-translocating P-type ATPase activity" NARROW[ EC:7 ]
    "calcium-transporting ATPase activity" EXACT
    "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW
Secondary IDs
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EC:7.2.2.10
MetaCyc:TRANS-RXN-194
Reactome:R-HSA-418309 "ATP2B1-4 transport cytosolic Ca2+ to extracellular region"
Reactome:R-HSA-418365 "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen"
Reactome:R-HSA-427910 "ATP2A1-3 transport Ca2+ from cytosol to ER lumen"
Reactome:R-HSA-936883 "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen"
Reactome:R-HSA-9662114 "ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region"
Reactome:R-HSA-9664214 "ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region"
RHEA:18105