FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term calcium:sodium antiporter activity ID (Ontology) GO:0005432 (Gene Ontology)
Definition Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).[ PubMed:16371597 ]
Also Known As "sodium/calcium exchanger"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 calcium:sodium antiporter activity (all annotations which use CV term, excluding "NOT" statements)
     enables | calcium:sodium antiporter activity       --
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calcium ion transmembrane transporter activity
 |__calcium:monoatomic cation antiporter activity___
metal ion transmembrane transporter activity        |
 |__sodium ion transmembrane transporter activity___|
metal cation:monoatomic cation antiporter activity  |
 |__calcium:monoatomic cation antiporter activity___|
                                                    calcium:sodium antiporter activity  14 rec.
                                                     |__calcium, potassium:sodium antiporter activity 6 rec.
                                                     |__calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
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Is a sodium ion transmembrane transporter activity
calcium:monoatomic cation antiporter activity
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Synonyms
  • "mitochondrial sodium/calcium ion exchange" RELATED
    "sodium/calcium exchanger" EXACT
    "sodium:calcium exchange" RELATED
Secondary IDs
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Reactome:R-HSA-425661 "SLC8A1,2,3 exchange 3Na+ for Ca2+"
Reactome:R-HSA-8949688 "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)"
Reactome:R-HSA-8949703 "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)"
RHEA:29255