FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term anaphase-promoting complex ID (Ontology) GO:0005680 (Gene Ontology)
Definition A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.[ PubMed:10465783 PubMed:10611969 ]
Also Known As"anaphase promoting complex" ; "cyclosome"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 anaphase-promoting complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | anaphase-promoting complex       --
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ubiquitin ligase complex
 |__nuclear ubiquitin ligase complex______
 |__cullin-RING ubiquitin ligase complex__|
nuclear protein-containing complex        |
 |__nuclear ubiquitin ligase complex______|
                                          anaphase-promoting complex  19 rec.
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Is a nuclear ubiquitin ligase complex
cullin-RING ubiquitin ligase complex
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Synonyms
  • "anaphase promoting complex" EXACT
    "APC" BROAD
    "cyclosome" EXACT
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Wikipedia:Anaphase-promoting_complex