FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term TIM23 mitochondrial import inner membrane translocase complex ID (Ontology) GO:0005744 (Gene Ontology)
Definition The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.[ PubMed:27554484 PubMed:8851659 ]
Also Known As"mitochondrial inner membrane pre-sequence translocase complex" ; "mitochondrial inner membrane presequence translocase complex" ; "Tim23 complex"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_CELLULAR_COMPONENT
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 TIM23 mitochondrial import inner membrane translocase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | TIM23 mitochondrial import inner membrane translocase complex       --
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mitochondrial inner membrane______________
membrane protein complex__________________|
mitochondrial protein-containing complex__|
                                          inner mitochondrial membrane protein complex
                                           |__TIM23 mitochondrial import inner membrane translocase complex  26 rec.
                                               |__PAM complex, Tim23 associated import motor 8 rec.
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Is a inner mitochondrial membrane protein complex
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Synonyms
  • "mitochondrial inner membrane pre-sequence translocase complex" EXACT
    "mitochondrial inner membrane presequence translocase complex" EXACT
    "mitochondrial inner membrane translocase complex" BROAD
    "Tim23 complex" EXACT
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