FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term mitochondrial permeability transition pore complex ID (Ontology) GO:0005757 (Gene Ontology)
Definition A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).[ PubMed:10393078 ]
Also Known As"mitochondrial PT pore complex" ; "MPTP complex"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
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 mitochondrial permeability transition pore complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | mitochondrial permeability transition pore complex
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mitochondrion
 |__mitochondrial envelope____________________
 |__mitochondrial protein-containing complex__|
organelle envelope                            |
 |__mitochondrial envelope____________________|
protein-containing complex                    |
 |__mitochondrial protein-containing complex__|
membrane protein complex                      |
 |__pore complex______________________________|
                                              mitochondrial permeability transition pore complex  2 rec.
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Is a pore complex
mitochondrial protein-containing complex
Part of mitochondrial envelope
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Synonyms
  • "mitochondrial PT pore complex" EXACT
    "MPTP complex" EXACT
    "PTPC" BROAD[ PubMed:21760595 ]
Secondary IDs
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