FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term glycerol-3-phosphate shuttle ID (Ontology) GO:0006127 (Gene Ontology)
Definition The process of transferring reducing equivalents from NADH in the cytosol into the mitochondria via glycerol-3-phosphate. Cytosolic glycerol-3-phosphate dehydrogenase uses NADH to convert dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate (G3P) in the cytosol; G3P then diffuses into the mitochondria where mitochondrial glycerol-3-phosphate dehydrogenase uses FAD to convert G3P back to DHAP; the electrons on the reduced FADH2 are then available for use in the electron transport chain, and DHAP returns to the cytosol to complete the cycle.[ PubMed:16368075 ]
Also Known As"glycerol phosphate shuttle" ; "glycerophosphate shuttle"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 glycerol-3-phosphate shuttle (all annotations which use CV term, excluding "NOT" statements)
     involved_in | glycerol-3-phosphate shuttle       --
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purine nucleotide metabolic process________
nicotinamide nucleotide metabolic process__|
                                           NAD+ metabolic process
                                            |__glycerol-3-phosphate shuttle  5 rec.
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Is a NAD+ metabolic process
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  • "glycerol phosphate shuttle" EXACT
    "glycerophosphate shuttle" EXACT
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MetaCyc:PWY-6118