FB2026_03 , released September 17, 2026
CV Term Report
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Term double-strand break repair via nonhomologous end joining ID (Ontology) GO:0006303 (Gene Ontology)
Definition The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.[ PubMed:10827453 PubMed:24837021 ]
Also Known As"NHEJ"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 double-strand break repair via nonhomologous end joining (all annotations which use CV term, excluding "NOT" statements)
     involved_in | double-strand break repair via nonhomologous end joining
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  DNA repair
   |__double-strand break repair
       |__double-strand break repair via nonhomologous end joining  11 rec.
           |__double-strand break repair via alternative nonhomologous end joining 2 rec.
           |__double-strand break repair via classical nonhomologous end joining
           |__gap filling involved in double-strand break repair via nonhomologous end joining
           |__regulation of double-strand break repair via nonhomologous end joining
               |__negative regulation of double-strand break repair via nonhomologous end joining
               |__positive regulation of double-strand break repair via nonhomologous end joining
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Is a double-strand break repair
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Reactome:R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)"