FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term DNA-templated transcription initiation ID (Ontology) GO:0006352 (Gene Ontology)
Definition The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.[ PubMed:18280161 ]
Also Known As"DNA-dependent RNA polymerase complex assembly at promoter" ; "DNA-dependent transcription, initiation" ; "DNA-templated transcription, initiation" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 DNA-templated transcription initiation (all annotations which use CV term, excluding "NOT" statements)
     involved_in | DNA-templated transcription initiation
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gene expression
 |__DNA-templated transcription____
RNA metabolic process              |
 |__RNA biosynthetic process_______|
RNA biosynthetic process           |
 |__DNA-templated transcription____|
nucleic acid biosynthetic process  |
 |__RNA biosynthetic process_______|
                                   DNA-templated transcription initiation  131 rec.
                                    |__DNA-templated transcription open complex formation 6 rec.
                                    |   |__transcription open complex formation at RNA polymerase II promoter(+) 6 rec.
                                    |__DNA-templated transcriptional start site selection 9 rec.
                                    |   |__transcriptional start site selection at RNA polymerase II promoter(+) 9 rec.
                                    |   |__transcriptional start site selection at RNA polymerase III promoter
                                    |__regulation of DNA-templated transcription initiation 20 rec.
                                    |   |__negative regulation of DNA-templated transcription initiation(+) 1 rec.
                                    |   |__positive regulation of DNA-templated transcription initiation(+) 9 rec.
                                    |   |__regulation of transcription initiation by RNA polymerase I
                                    |   |__regulation of transcription initiation by RNA polymerase II(+) 20 rec.
                                    |__transcription initiation at mitochondrial promoter 2 rec.
                                    |__transcription initiation at RNA polymerase I promoter 3 rec.
                                    |   |__regulation of transcription initiation by RNA polymerase I
                                    |   |__RNA polymerase I preinitiation complex assembly 2 rec.
                                    |__transcription initiation at RNA polymerase II promoter 114 rec.
                                    |   |__regulation of transcription initiation by RNA polymerase II(+) 20 rec.
                                    |   |__RNA polymerase II preinitiation complex assembly(+) 19 rec.
                                    |   |__RNA polymerase II transcription initiation surveillance 16 rec.
                                    |   |__transcription initiation-coupled chromatin remodeling(+) 16 rec.
                                    |   |__transcription open complex formation at RNA polymerase II promoter(+) 6 rec.
                                    |   |__transcriptional start site selection at RNA polymerase II promoter(+) 9 rec.
                                    |__transcription initiation at RNA polymerase III promoter 9 rec.
                                    |   |__RNA polymerase III preinitiation complex assembly 1 rec.
                                    |   |__transcriptional start site selection at RNA polymerase III promoter
                                    |__transcription preinitiation complex assembly 23 rec.
                                        |__RNA polymerase I preinitiation complex assembly 2 rec.
                                        |__RNA polymerase II preinitiation complex assembly(+) 19 rec.
                                        |__RNA polymerase III preinitiation complex assembly 1 rec.
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Is a RNA biosynthetic process
Part of DNA-templated transcription
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Synonyms
  • "DNA-dependent RNA polymerase complex assembly at promoter" EXACT
    "DNA-dependent transcription, initiation" EXACT
    "DNA-templated transcription, initiation" EXACT
    "initiation of DNA-dependent transcription" EXACT
    "initiation of transcription, DNA-dependent" EXACT
    "transcription initiation factor activity" RELATED
    "transcription initiation from bacterial-type RNA polymerase promoter" NARROW
    "transcription initiation, DNA-dependent" RELATED
Secondary IDs
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