FB2026_03 , released September 17, 2026
CV Term Report
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Term rRNA processing ID (Ontology) GO:0006364 (Gene Ontology)
Definition Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 Genes
 rRNA processing (all annotations which use CV term, excluding "NOT" statements)
     involved_in | rRNA processing
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gene expression
 |__RNA processing____________________
RNA metabolic process                 |
 |__rRNA metabolic process____________|
ribonucleoprotein complex biogenesis  |
 |__ribosome biogenesis_______________|
RNA biosynthetic process              |
 |__RNA processing____________________|
primary metabolic process             |
 |__RNA processing____________________|
                                      rRNA processing  183 rec.
                                       |__chloroplast rRNA processing
                                       |__cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA)
                                       |__endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) 1 rec.
                                       |   |__cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
                                       |   |__cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
                                       |   |__cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
                                       |__endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
                                       |   |__endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
                                       |   |__endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
                                       |   |__endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
                                       |__endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 34 rec.
                                       |   |__cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3 rec.
                                       |   |__endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
                                       |   |__endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 21 rec.
                                       |   |__endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 23 rec.
                                       |   |__endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
                                       |   |__endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 rec.
                                       |   |__endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 18 rec.
                                       |__endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
                                       |   |__endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
                                       |   |__endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
                                       |__maturation of 2S rRNA
                                       |   |__cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
                                       |   |__cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
                                       |__maturation of 4.5S rRNA
                                       |__maturation of 5.8S rRNA 44 rec.
                                       |   |__maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)(+)
                                       |   |__maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(+) 38 rec.
                                       |__maturation of 5S rRNA 1 rec.
                                       |   |__generation of mature 3'-end of 5S rRNA generated by RNA polymerase III
                                       |   |__maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
                                       |__maturation of LSU-rRNA 32 rec.
                                       |   |__maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)(+)
                                       |   |__maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
                                       |   |__maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(+) 25 rec.
                                       |   |__maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)(+)
                                       |__maturation of SSU-rRNA 69 rec.
                                       |   |__maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)(+)
                                       |   |__maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
                                       |   |__maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(+) 50 rec.
                                       |   |__maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)(+)
                                       |   |__rRNA acetylation involved in maturation of SSU-rRNA 2 rec.
                                       |__regulation of rRNA processing 1 rec.
                                       |   |__negative regulation of rRNA processing
                                       |   |__positive regulation of rRNA processing 1 rec.
                                       |__rRNA 3'-end processing 11 rec.
                                       |   |__endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 rec.
                                       |   |__exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 7 rec.
                                       |   |__generation of mature 3'-end of 5S rRNA generated by RNA polymerase III
                                       |   |__generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
                                       |__rRNA 5'-end processing 18 rec.
                                       |   |__endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 18 rec.
                                       |   |__exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
                                       |   |__generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
                                       |__rRNA modification 31 rec.
                                       |   |__cotranscriptional mitochondrial rRNA nucleotide insertion
                                       |   |__rRNA acetylation(+) 2 rec.
                                       |   |__rRNA methylation(+) 19 rec.
                                       |   |__rRNA pseudouridine synthesis(+) 9 rec.
                                       |__snoRNA release from pre-rRNA
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Is a RNA processing
rRNA metabolic process
Part of ribosome biogenesis
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Synonyms
  • "35S primary transcript processing" NARROW
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-72312 "rRNA processing"