FB2026_03 , released September 17, 2026
CV Term Report
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Term tRNA modification ID (Ontology) GO:0006400 (Gene Ontology)
Definition The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_CELLULAR_COMPONENT
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 tRNA modification (all annotations which use CV term, excluding "NOT" statements)
     involved_in | tRNA modification
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RNA processing
 |__tRNA processing_________
tRNA metabolic process      |
 |__tRNA processing_________|
RNA metabolic process       |
 |__RNA modification________|
macromolecule modification  |
 |__RNA modification________|
                            tRNA modification  73 rec.
                             |__archaeosine-tRNA biosynthetic process
                             |__charged-tRNA amino acid modification 2 rec.
                             |   |__conversion of aspartyl-tRNA to asparaginyl-tRNA
                             |   |__conversion of glutamyl-tRNA to glutaminyl-tRNA
                             |   |__conversion of lysyl-tRNA to pyrrolysyl-tRNA
                             |   |__conversion of methionyl-tRNA to N-formyl-methionyl-tRNA 1 rec.
                             |   |__conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA
                             |   |__conversion of seryl-tRNAsec to selenocys-tRNAsec 1 rec.
                             |__cyclic threonylcarbamoyladenosine biosynthetic process
                             |__mitochondrial tRNA modification 12 rec.
                             |   |__mitochondrial tRNA methylation 2 rec.
                             |   |__mitochondrial tRNA pseudouridine synthesis 2 rec.
                             |   |__mitochondrial tRNA thio-modification(+) 2 rec.
                             |   |__mitochondrial tRNA threonylcarbamoyladenosine modification 1 rec.
                             |   |__mitochondrial tRNA wobble uridine modification(+) 4 rec.
                             |__regulation of translational initiation by tRNA modification
                             |__tRNA acetylation 1 rec.
                             |__tRNA adenosine deamination to inosine
                             |__tRNA dihydrouridine synthesis 1 rec.
                             |__tRNA methylation 25 rec.
                             |   |__5-carbamoylmethyl uridine residue modification
                             |   |__mitochondrial tRNA methylation 2 rec.
                             |   |__regulation of tRNA methylation(+)
                             |   |__tRNA (guanine-N7)-methylation
                             |   |__tRNA C3-cytosine methylation 1 rec.
                             |   |__tRNA C5-cytosine methylation(+) 1 rec.
                             |   |__tRNA m2,2-guanine biosynthesis
                             |   |__tRNA N1-guanine methylation 2 rec.
                             |   |__tRNA N2-guanine methylation 1 rec.
                             |   |__tRNA nucleoside ribose methylation(+) 5 rec.
                             |__tRNA methylthiolation 1 rec.
                             |__tRNA pseudouridine synthesis 6 rec.
                             |   |__mitochondrial tRNA pseudouridine synthesis 2 rec.
                             |__tRNA seleno-modification
                             |__tRNA thio-modification 6 rec.
                             |   |__mitochondrial tRNA thio-modification(+) 2 rec.
                             |   |__tRNA 4-thiouridine biosynthesis
                             |   |__tRNA wobble position uridine thiolation(+) 4 rec.
                             |__tRNA threonylcarbamoyladenosine modification 4 rec.
                             |   |__mitochondrial tRNA threonylcarbamoyladenosine modification 1 rec.
                             |__tRNA wobble base modification 25 rec.
                             |   |__tRNA wobble adenosine to inosine editing 1 rec.
                             |   |__tRNA wobble cytosine modification(+) 3 rec.
                             |   |__tRNA wobble guanine modification(+) 2 rec.
                             |   |__tRNA wobble uridine modification(+) 18 rec.
                             |__wybutosine biosynthetic process
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Is a tRNA processing
RNA modification
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Synonyms
  • "tRNA editing" NARROW
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Reactome:R-HSA-6782315 "tRNA modification in the nucleus and cytosol"