FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term GPI anchor biosynthetic process ID (Ontology) GO:0006506 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.[ ISBN:0198547684 ]
Also Known As"glycosylphosphatidylinositol biosynthesis" ; "glycosylphosphatidylinositol biosynthetic process" ; "GPI anchor anabolism" (for all, see Synonyms field below)
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 GPI anchor biosynthetic process (all annotations which use CV term, excluding "NOT" statements)
     involved_in | GPI anchor biosynthetic process       --
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glycerophospholipid metabolic process
 |__GPI anchor metabolic process______________
 |__glycerophospholipid biosynthetic process__|
glycolipid metabolic process                  |
 |__GPI anchor metabolic process______________|
 |__glycolipid biosynthetic process___________|
lipid biosynthetic process                    |
 |__glycolipid biosynthetic process___________|
phospholipid biosynthetic process             |
 |__glycerophospholipid biosynthetic process__|
glycerolipid biosynthetic process             |
 |__glycerophospholipid biosynthetic process__|
protein maturation                            |
 |__GPI anchored protein biosynthesis_________|
carbohydrate derivative biosynthetic process  |
 |__glycolipid biosynthetic process___________|
                                              GPI anchor biosynthetic process  35 rec.
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Is a GPI anchor metabolic process
glycolipid biosynthetic process
glycerophospholipid biosynthetic process
Part of GPI anchored protein biosynthesis
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Synonyms
  • "glycosylphosphatidylinositol biosynthesis" EXACT
    "glycosylphosphatidylinositol biosynthetic process" EXACT
    "GPI anchor anabolism" EXACT
    "GPI anchor biosynthesis" EXACT
    "GPI anchor formation" EXACT
    "GPI anchor synthesis" EXACT
    "GPI/GSI anchor biosynthesis" BROAD
    "GPI/GSI anchor biosynthetic process" BROAD
Secondary IDs
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MetaCyc:PWY-8600
MetaCyc:PWY-8601
Reactome:R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)"