FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term GABA shunt ID (Ontology) GO:0006540 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of succinate from L-glutamate via gamma-aminobutyrate (GABA), bypassing two steps of the TCA cycle. It operates through the sequential conversion of glutamate to GABA by glutamate decarboxylase, transamination of GABA to succinic semialdehyde by GABA transaminase, and oxidation of succinic semialdehyde to succinate by succinate semialdehyde dehydrogenase.[ PubMed:39703920 ]
Also Known As "4-aminobutyrate shunt" ; "gamma aminobutyrate shunt" ; "gamma-aminobutyrate shunt" (for all, see Synonyms field below)
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       1
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Relevant FlyBase reports
 Gene Groups Genes
 GABA shunt (all annotations which use CV term, excluding "NOT" statements)       1      1
     involved_in | GABA shunt       --       1
Spanning Tree (Parents/Children)
Only view relationship: 
amino acid metabolic process
 |__proteinogenic amino acid metabolic process__
carboxylic acid metabolic process               |
 |__proteinogenic amino acid metabolic process__|
dicarboxylic acid metabolic process             |
 |__succinate metabolic process_________________|
 |__glutamate metabolic process_________________|
alpha-amino acid metabolic process              |
 |__glutamate metabolic process_________________|
 |__L-amino acid metabolic process______________|
                                                GABA shunt  2 rec.
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Is a succinate metabolic process
glutamate metabolic process
L-amino acid metabolic process
proteinogenic amino acid metabolic process
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Synonyms
  • "4-aminobutyrate shunt" EXACT
    "gamma aminobutyrate shunt" EXACT
    "gamma-aminobutyrate shunt" EXACT
    "glutamate decarboxylation to succinate" EXACT
Secondary IDs
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MetaCyc:GLUDEG-I-PWY
MetaCyc:PWY-8346