FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term GABA shunt ID (Ontology) GO:0006540 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of succinate from L-glutamate via gamma-aminobutyrate (GABA), bypassing two steps of the TCA cycle. It operates through the sequential conversion of glutamate to GABA by glutamate decarboxylase, transamination of GABA to succinic semialdehyde by GABA transaminase, and oxidation of succinic semialdehyde to succinate by succinate semialdehyde dehydrogenase.[ PubMed:39703920 ]
Also Known As"4-aminobutyrate shunt" ; "gamma aminobutyrate shunt" ; "gamma-aminobutyrate shunt" (for all, see Synonyms field below)
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 GABA shunt (all annotations which use CV term, excluding "NOT" statements)
     involved_in | GABA shunt       --
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amino acid metabolic process
 |__glutamate metabolic process_________________
 |__proteinogenic amino acid metabolic process__|
carboxylic acid metabolic process               |
 |__proteinogenic amino acid metabolic process__|
dicarboxylic acid metabolic process             |
 |__succinate metabolic process_________________|
 |__glutamate metabolic process_________________|
                                                GABA shunt  4 rec.
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Is a succinate metabolic process
glutamate metabolic process
proteinogenic amino acid metabolic process
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Synonyms
  • "4-aminobutyrate shunt" EXACT
    "gamma aminobutyrate shunt" EXACT
    "gamma-aminobutyrate shunt" EXACT
    "glutamate decarboxylation to succinate" EXACT
Secondary IDs
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MetaCyc:GLUDEG-I-PWY
MetaCyc:PWY-8346