FB2026_03 , released September 17, 2026
CV Term Report
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Term SRP-dependent cotranslational protein targeting to membrane ID (Ontology) GO:0006614 (Gene Ontology)
Definition The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.[ ISBN:0716731363 ]
Also Known As"SRP-dependent cotranslational membrane targeting" ; "SRP-dependent cotranslational protein-membrane targeting"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 SRP-dependent cotranslational protein targeting to membrane (all annotations which use CV term, excluding "NOT" statements)
     involved_in | SRP-dependent cotranslational protein targeting to membrane       --
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protein targeting
 |__protein targeting to ER_____________________________________
protein targeting to membrane                                   |
 |__cotranslational protein targeting to membrane_______________|
establishment of protein localization to endoplasmic reticulum  |
 |__protein targeting to ER_____________________________________|
                                                                SRP-dependent cotranslational protein targeting to membrane  24 rec.
                                                                 |__SRP-dependent cotranslational protein targeting to membrane, docking 1 rec.
                                                                 |__SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 3 rec.
                                                                 |__SRP-dependent cotranslational protein targeting to membrane, translocation 13 rec.
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Is a cotranslational protein targeting to membrane
protein targeting to ER
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Synonyms
  • "ER translocation" BROAD
    "SRP-dependent cotranslational membrane targeting" EXACT
    "SRP-dependent cotranslational protein-membrane targeting" EXACT
Secondary IDs
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Reactome:R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane"