FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term NADPH regeneration ID (Ontology) GO:0006740 (Gene Ontology)
Definition A metabolic process that replenishes the cellular or compartmental pool of NADPH by transfer of reducing equivalents from a donor substrate to NADP+, independent of the route or compartment involved.[ PubMed:33028807 PubMed:34074675 ]
Also Known As"NADP (reduced) regeneration" ; "NADPH replenishment" ; "reduced NADP regeneration" (for all, see Synonyms field below)
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 NADPH regeneration (all annotations which use CV term, excluding "NOT" statements)
     involved_in | NADPH regeneration       --
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purine nucleotide metabolic process
 |__NADP+ metabolic process_________________________
metabolic process                                   |
 |__generation of precursor metabolites and energy__|
nicotinamide nucleotide metabolic process           |
 |__NADP+ metabolic process_________________________|
                                                    NADPH regeneration  16 rec.
                                                     |__pentose-phosphate shunt 10 rec.
                                                     |   |__pentose-phosphate shunt, non-oxidative branch 5 rec.
                                                     |   |__pentose-phosphate shunt, oxidative branch 3 rec.
                                                     |   |__regulation of pentose-phosphate shunt(+) 1 rec.
                                                     |__pentose-phosphate shunt, oxidative branch 3 rec.
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Is a generation of precursor metabolites and energy
NADP+ metabolic process
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Synonyms
  • "NADP (reduced) regeneration" EXACT
    "NADPH replenishment" EXACT
    "reduced NADP regeneration" EXACT
    "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXACT
Secondary IDs
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Reactome:R-HSA-389542 "NADPH regeneration"