FB2026_03 , released September 17, 2026
CV Term Report
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Term metaphase/anaphase transition of mitotic cell cycle ID (Ontology) GO:0007091 (Gene Ontology)
Definition The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.[ PubMed:10465783 ]
Also Known As"metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" ; "mitotic metaphase/anaphase transition"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 metaphase/anaphase transition of mitotic cell cycle (all annotations which use CV term, excluding "NOT" statements)
     involved_in | metaphase/anaphase transition of mitotic cell cycle
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regulation of sister chromatid segregation
 |__metaphase/anaphase transition of cell cycle__
cell cycle phase transition                      |
 |__mitotic cell cycle phase transition__________|
 |__metaphase/anaphase transition of cell cycle__|
mitotic cell cycle process                       |
 |__mitotic cell cycle phase transition__________|
                                                 metaphase/anaphase transition of mitotic cell cycle  34 rec.
                                                  |__regulation of mitotic metaphase/anaphase transition 27 rec.
                                                      |__negative regulation of mitotic metaphase/anaphase transition(+) 13 rec.
                                                      |__positive regulation of mitotic metaphase/anaphase transition(+) 10 rec.
                                                      |__regulation of mitotic cell cycle spindle assembly checkpoint(+) 4 rec.
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Is a mitotic cell cycle phase transition
metaphase/anaphase transition of cell cycle
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Synonyms
  • "metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT
    "mitotic metaphase/anaphase transition" EXACT
Secondary IDs
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Reactome:R-HSA-68881 "Mitotic Metaphase/Anaphase Transition"