FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

smoothened signaling pathway

ID (Ontology)

GO:0007224 (Gene Ontology)

Definition

The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.[ PubMed:15057936 PubMed:15205520 ]

Also Known As

"hedgehog signaling pathway" ; "smoothened signalling pathway"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
smoothened signaling pathway (all annotations which use CV term, excluding "NOT" statements)
involved_in \| smoothened signaling pathway	--
NOT \| involved_in \| smoothened signaling pathway	--

Spanning Tree (Parents/Children)

  signal transduction
   |__cell surface receptor signaling pathway
       |__smoothened signaling pathway  104 rec.
           |__mesenchymal smoothened signaling pathway involved in prostate gland development
           |__regulation of smoothened signaling pathway 96 rec.
           |   |__negative regulation of smoothened signaling pathway(+) 60 rec.
           |   |__positive regulation of smoothened signaling pathway 46 rec.
           |   |__regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(+)
           |__smoothened signaling pathway involved in dorsal/ventral neural tube patterning
           |   |__regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(+)
           |__smoothened signaling pathway involved in lung development
           |__smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
           |__smoothened signaling pathway involved in ventral spinal cord patterning
               |__smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
               |__smoothened signaling pathway involved in ventral spinal cord interneuron specification

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	cell surface receptor signaling pathway
Part of
Synonyms & Secondary IDs
Synonyms
	"hedgehog signaling pathway" EXACT "hh signaling pathway" NARROW "hh signalling pathway" NARROW "Shh signaling pathway" RELATED "smoothened signalling pathway" EXACT "Sonic hedgehog signaling pathway" NARROW
Secondary IDs

External Crossreferences & Linkouts
	Wikipedia:Hedgehog_signaling_pathway