FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

canonical NF-kappaB signal transduction

ID (Ontology)

GO:0007249 (Gene Ontology)

Definition

An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).[ PubMed:12773372 PubMed:34659217 ]

Also Known As

"canonical NF-kappaB signaling cascade" ; "I-kappaB kinase/NF-kappaB cascade" ; "I-kappaB kinase/NF-kappaB signal transduction" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
canonical NF-kappaB signal transduction (all annotations which use CV term, excluding "NOT" statements)
involved_in \| canonical NF-kappaB signal transduction

Spanning Tree (Parents/Children)

  intracellular signal transduction
   |__intracellular signaling cassette
       |__canonical NF-kappaB signal transduction  14 rec.
           |__I-kappaB phosphorylation
           |   |__regulation of I-kappaB phosphorylation(+)
           |__regulation of canonical NF-kappaB signal transduction 11 rec.
               |__negative regulation of canonical NF-kappaB signal transduction 3 rec.
               |__positive regulation of canonical NF-kappaB signal transduction 6 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	intracellular signaling cassette
Part of
Synonyms & Secondary IDs
Synonyms
	"canonical NF-kappaB signaling cascade" EXACT "I-kappaB kinase/NF-kappaB cascade" EXACT "I-kappaB kinase/NF-kappaB signal transduction" EXACT "I-kappaB kinase/NF-kappaB signaling" EXACT "NF-kappaB cascade" BROAD "p50-dependent NF-kappaB signaling" RELATED[ PubMed:18292232 ]
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-5357956 "TNFR1-induced NF-kappa-B signaling pathway" Reactome:R-HSA-9014325 "TICAM1,TRAF6-dependent induction of TAK1 complex" Reactome:R-HSA-937072 "TRAF6-mediated induction of TAK1 complex within TLR4 complex"