FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

peptide-methionine (S)-S-oxide reductase activity

ID (Ontology)

GO:0008113 (Gene Ontology)

Definition

Catalysis of the reaction: L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol.

Also Known As

"methionine sulfoxide (protein) reductase activity" ; "peptide-methionine-(S)-S-oxide reductase activity" ; "protein-methionine-S-oxide reductase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
peptide-methionine (S)-S-oxide reductase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| peptide-methionine (S)-S-oxide reductase activity

Spanning Tree (Parents/Children)

catalytic activity
 |__catalytic activity, acting on a protein_____________________________________________
oxidoreductase activity, acting on a sulfur group of donors                             |
 |__oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor__|
                                                                                        peptide-methionine (S)-S-oxide reductase activity  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor catalytic activity, acting on a protein
Part of
Synonyms & Secondary IDs
Synonyms
	"methionine sulfoxide (protein) reductase activity" EXACT "peptide-methionine-(S)-S-oxide reductase activity" EXACT "protein-methionine-S-oxide reductase activity" EXACT
Secondary IDs

External Crossreferences & Linkouts
	MetaCyc:RXN-8668 Reactome:R-HSA-1222363 "MsrA/B reduces peptide-methionine S/R-sulfoxides" Reactome:R-HSA-5676940 "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine" RHEA:14217