FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term 4-alpha-hydroxytetrahydrobiopterin dehydratase activity ID (Ontology) GO:0008124 (Gene Ontology)
Definition Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.[ EC:4 ]
Also Known As"4a-hydroxytetrahydrobiopterin dehydratase activity" ; "pterin-4-alpha-carbinolamine dehydratase activity" ; "pterin-4a-carbinolamine dehydratase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 4-alpha-hydroxytetrahydrobiopterin dehydratase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity
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  carbon-oxygen lyase activity
   |__hydro-lyase activity
       |__4-alpha-hydroxytetrahydrobiopterin dehydratase activity  1 rec.
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Is a hydro-lyase activity
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Synonyms
  • "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED
    "4-alpha-hydroxy-tetrahydropterin dehydratase activity" RELATED[ EC:4 ]
    "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT
    "4a-hydroxytetrahydrobiopterin hydro-lyase activity" RELATED[ EC:4 ]
    "4alpha-hydroxy-tetrahydropterin dehydratase activity" RELATED[ EC:4 ]
    "pterin-4-alpha-carbinolamine dehydratase activity" EXACT
    "pterin-4a-carbinolamine dehydratase activity" EXACT
    "pterin-4alpha-carbinolamine dehydratase activity" RELATED
    "tetrahydrobiopterin dehydratase activity" RELATED[ EC:4 ]
Secondary IDs
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EC:4.2.1.96
KEGG_REACTION:R04734
MetaCyc:RXN-7908
Reactome:R-HSA-71146 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O"
RHEA:11920